LymphedemaV1, Main, Exploration, bibRecord, 006F94

Impact of seven rounds of mass administration of diethylcarbamazine and ivermectin on prevalence of chronic lymphatic filariasis in south India

Identifieur interne : 006F94 ( Main/Exploration ); précédent : 006F93; suivant : 006F95

Impact of seven rounds of mass administration of diethylcarbamazine and ivermectin on prevalence of chronic lymphatic filariasis in south India

Auteurs : J. Yuvaraj [Inde] ; S. P. Pani [Inde] ; P. Vanamail [Inde] ; K. D. Ramaiah [Inde] ; P. K. Das [Inde]

Source :

TM & IH. Tropical medicine & international health [ 1360-2276 ] ; 2008.

RBID : Pascal:08-0227645

Descripteurs français

Pascal (Inist)
- Diéthylcarbamazine, Ivermectine, Filariose lymphatique, Maladie chronique, Lymphoedème, Hydrocèle, Campagne de masse, Prévalence, Chronique, Sud, Inde, Médicament, Médecine tropicale, Antiparasitaire, Anthelminthique, Epanchement.
Wicri :
- geographic : Inde.
- topic : Maladie chronique, Médicament.

English descriptors

KwdEn :
- Anthelmintic, Chronic, Chronic disease, Diethylcarbamazine, Drug, Effusion, Hydrocele, India, Ivermectin, Lymphatic filariasis, Lymphedema, Mass campaign, Parasiticide, Prevalence, South, Tropical medicine.

Abstract

OBJECTIVE To evaluate the impact of seven rounds of mass administration of diethylcarbamazine (DEC) and ivermectin on the prevalence of chronic lymphatic filariasis and to compare it with that observed in a placebo arm in a community-level trial. METHODS Cross-sectional clinical surveys were carried out before and after seven rounds of mass drug administration (MDA). About 54-75% of the target population were treated at each round of MDA. RESULTS After seven rounds, the hydrocele prevalence had declined from the pre-intervention level of 20.5-5.1% (P < 0.05) in the DEC arm, from 23.9% to 10.4% (P < 0.05) in the ivermectin arm and from 20.4% to 10.9% (P < 0.05) in the placebo arm, equivalent to reductions of 75.3%, 56.6% and 46.6%, respectively. The lymphoedema/elephantiasis prevalence declined only marginally and without statistical significance from 3.7% to 3.2%, 4.6% to 3.9% and 2.9% to 2.3% in the DEC, ivermectin and placebo arm. After the seventh MDA, none of the sampled people in the 0-20 age group was found with hydrocele and there was a statistically significant decline in hydrocele prevalence in all other age groups in the communities treated with DEC, the drug known to have macrofilaricidal effect. The impact was relatively less in ivermectin arm. CONCLUSION Repeated DEC administration has the potential to prevent incidence of new hydrocele cases and may resolve the manifestation at least in a proportion of affected people. Apart from reducing the microfilaraemia prevalence and transmission of infection, MDA also results in significant public health benefits by reducing the burden of hydrocele in treated communities.

Affiliations:

Inde

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Le document en format XML

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<term>Chronic disease</term>
<term>Diethylcarbamazine</term>
<term>Drug</term>
<term>Effusion</term>
<term>Hydrocele</term>
<term>India</term>
<term>Ivermectin</term>
<term>Lymphatic filariasis</term>
<term>Lymphedema</term>
<term>Mass campaign</term>
<term>Parasiticide</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Diéthylcarbamazine</term>
<term>Ivermectine</term>
<term>Filariose lymphatique</term>
<term>Maladie chronique</term>
<term>Lymphoedème</term>
<term>Hydrocèle</term>
<term>Campagne de masse</term>
<term>Prévalence</term>
<term>Chronique</term>
<term>Sud</term>
<term>Inde</term>
<term>Médicament</term>
<term>Médecine tropicale</term>
<term>Antiparasitaire</term>
<term>Anthelminthique</term>
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<front><div type="abstract" xml:lang="en">OBJECTIVE To evaluate the impact of seven rounds of mass administration of diethylcarbamazine (DEC) and ivermectin on the prevalence of chronic lymphatic filariasis and to compare it with that observed in a placebo arm in a community-level trial. METHODS Cross-sectional clinical surveys were carried out before and after seven rounds of mass drug administration (MDA). About 54-75% of the target population were treated at each round of MDA. RESULTS After seven rounds, the hydrocele prevalence had declined from the pre-intervention level of 20.5-5.1% (P < 0.05) in the DEC arm, from 23.9% to 10.4% (P < 0.05) in the ivermectin arm and from 20.4% to 10.9% (P < 0.05) in the placebo arm, equivalent to reductions of 75.3%, 56.6% and 46.6%, respectively. The lymphoedema/elephantiasis prevalence declined only marginally and without statistical significance from 3.7% to 3.2%, 4.6% to 3.9% and 2.9% to 2.3% in the DEC, ivermectin and placebo arm. After the seventh MDA, none of the sampled people in the 0-20 age group was found with hydrocele and there was a statistically significant decline in hydrocele prevalence in all other age groups in the communities treated with DEC, the drug known to have macrofilaricidal effect. The impact was relatively less in ivermectin arm. CONCLUSION Repeated DEC administration has the potential to prevent incidence of new hydrocele cases and may resolve the manifestation at least in a proportion of affected people. Apart from reducing the microfilaraemia prevalence and transmission of infection, MDA also results in significant public health benefits by reducing the burden of hydrocele in treated communities.</div>
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Impact of seven rounds of mass administration of diethylcarbamazine and ivermectin on prevalence of chronic lymphatic filariasis in south India

Impact of seven rounds of mass administration of diethylcarbamazine and ivermectin on prevalence of chronic lymphatic filariasis in south India

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri